Sodium Picosulfate Oral Solution

Sodium picosulfate is in a class of medications called stimulant laxatives. Sodium picosulfate solution is used to clean out the intestines before surgery or certain procedures (such as colonoscopy, X-rays). It is a laxative that works by drawing large amounts of water into your intestines and stimulating the colon. This causes watery bowel movements (diarrhea).

Indicated for cleansing of the colon as a preparation for colonoscopy in adults. It is used as a treatment for constipation or to prepare the large bowel before colonoscopy or surgery.

Mechansium Of Action:

sodium picosulfate, is a contact laxative. Sodium picosulfate inhibits the absorption of water and electrolytes, and increases their secretion into the intestinal lumen . It is hydrolyzed by colonic bacterial enzyme, sulfatase , to form an active metabolite bis-(p-hydroxy-phenyl)-pyridyl-2-methane (BHPM), which acts directly on the colonic mucosa to stimulate colonic peristalsis. This compound is a stimulant laxative and increases peristalsis in the gut.

Pharmacokinetics:

Absorption: In healthy volunteers receiving 2 packets of sodium picosulfate in combination with magnesium oxide and anhydrous citric acid every 6 hours, the mean peak plasma concentrations (Cmax) of sodium picosulfate was achieved within 7 hours (Tmax) Label. The mean Cmax of its active metabolite, BHPM, was 0.05 ng/mL 
Metabolism: Sodium picosulfate is hydrolyzed by colonic bacteria to form an active metabolite bis-(p-hydroxy-phenyl)-pyridyl-2-methane (BHPM)
Elimination: Sodium picosulfate and its metabolite BHPM are mainly excreted in urine. The fraction of the absorbed sodium picosulfate dose excreted in urine as unchanged parent compound was 0.19% Label. Urinary recovery of BHPM was 0.01% of total administered drug Label. A small amount absorbed picosulfate is reported to be excreted in the urine as a glucuronide-conjugate of BHPM

Pharmacodynamics:

Sodium picosulfate is a stimulant laxative that in conjunction with magnesium citrate, produces a purgative effect on stools. In a multicentre, observational study comprising of patients undergoing colonoscopy, more than 93.0% of the patients receiving sodium picosulfate-containing preparations reported the colon cleansing effect to be effective.

Sodium Picosulfate Ferring is contraindicated in patients with ileus, gastrointestinal obstruction, gastrointestinal ulceration or perforation, acute abdominal surgical conditions including appendicitis, acute inflammatory bowel diseases.
Pregnant: Contact your doctor before taking this.

• Diarrhea.
• Head Pain.
• Nausea.
• Stomach Cramps.
• Swelling Of The Abdomen.
• Taste Impairment.
• Vomiting.